Assay Detail
Binding
CHEMBL761027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound that affords half-maximum transactivation of human Peroxisome proliferator activated receptor gamma in CHO-K1 cells was determined in vitro
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.83 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120009 | — | — | 1 | 6.40 |
| CHEMBL24458 | — | — | 1 | 6.10 |
| CHEMBL331206 | — | — | 1 | 5.60 |
| CHEMBL120744 | — | — | 1 | 5.55 |
| CHEMBL122009 | — | — | 1 | 5.52 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120009 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL24458 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL331206 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL120744 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL122009 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | > | 137000.0 | nM | - |