Assay Detail
Functional
CHEMBL761303
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Inhibitory activity against chloroquine-resistant Plasmodium falciparum FcB1R
68
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 7.39 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329816 | — | — | 1 | 8.43 |
| CHEMBL93504 | — | — | 1 | 8.36 |
| CHEMBL96676 | — | — | 1 | 8.34 |
| CHEMBL97247 | — | — | 1 | 8.30 |
| CHEMBL95138 | — | — | 1 | 8.26 |
| CHEMBL97277 | — | — | 1 | 8.26 |
| CHEMBL94587 | — | — | 1 | 8.19 |
| CHEMBL96938 | — | — | 3 | 8.18 |
| CHEMBL328172 | — | — | 1 | 8.16 |
| CHEMBL329809 | — | — | 1 | 8.16 |
| CHEMBL1630 | — | — | 1 | 8.13 |
| CHEMBL94554 | — | — | 1 | 8.12 |
| CHEMBL97611 | — | — | 1 | 8.07 |
| CHEMBL96064 | — | — | 1 | 8.04 |
| CHEMBL94521 | — | — | 1 | 8.02 |
| CHEMBL447526 | — | — | 1 | 7.99 |
| CHEMBL94832 | — | — | 1 | 7.96 |
| CHEMBL319162 | — | — | 1 | 7.94 |
| CHEMBL317348 | — | — | 1 | 7.94 |
| CHEMBL316654 | — | — | 1 | 7.92 |
| CHEMBL318927 | — | — | 1 | 7.90 |
| CHEMBL319141 | — | — | 1 | 7.89 |
| CHEMBL262298 | — | — | 1 | 7.88 |
| CHEMBL94992 | — | — | 1 | 7.88 |
| CHEMBL97395 | — | — | 1 | 7.85 |
| CHEMBL30020 | — | — | 1 | 7.81 |
| CHEMBL319756 | — | — | 1 | 7.81 |
| CHEMBL97062 | — | — | 1 | 7.67 |
| CHEMBL330238 | — | — | 1 | 7.64 |
| CHEMBL415499 | — | — | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329816 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL93504 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL96676 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL97247 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL97277 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL95138 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL94587 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL96938 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL328172 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL329809 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1630 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL94554 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL96938 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL97611 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL96064 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL94521 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL447526 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL96938 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL94832 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL317348 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL319162 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL316654 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL318927 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL319141 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL262298 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL94992 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL97395 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL319756 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL30020 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL97062 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL330238 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL415499 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL329354 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL94625 | — | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL96675 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL98566 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL97471 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL96248 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL72865 | — | IC50 | = | 65.1 | nM | 7.19 |
| CHEMBL329277 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL447527 | — | IC50 | = | 77.7 | nM | 7.11 |
| CHEMBL95041 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL317760 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL317958 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL98343 | — | IC50 | = | 135.5 | nM | 6.87 |
| CHEMBL98356 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL97296 | — | IC50 | = | 141.1 | nM | 6.85 |
| CHEMBL94429 | — | IC50 | = | 151.1 | nM | 6.82 |
| CHEMBL264750 | — | IC50 | = | 165.0 | nM | 6.78 |