Assay Detail
Functional
CHEMBL761307
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Displacement of chloroquine from Fe(3+) FPIX-loaded membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.75 |
| CHEMBL146617 | — | — | 1 | 5.41 |
| CHEMBL344105 | — | — | 1 | 5.23 |
| CHEMBL146616 | — | — | 1 | 5.12 |
| CHEMBL146945 | — | — | 1 | 5.08 |
| CHEMBL148139 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL146617 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL344105 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL146616 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL146945 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL148139 | — | IC50 | = | 24900.0 | nM | 4.60 |