Assay Detail
Binding
CHEMBL761554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of guinea pig ventricular Phosphodiesterase 3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.55 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.14 |
| CHEMBL414613 | — | — | 1 | 5.29 |
| CHEMBL29546 | — | — | 1 | 5.23 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL414613 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL29546 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 242000.0 | nM | - |