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Assay Detail

CHEMBL761557

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory potency against guinea pig ventricular phosphodiesterase 3
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 3 (CHEMBL2094125)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and biological evaluation of 2,5-dihydropyrazol.
Crespo MI, Gràcia J, Puig C, Vega A, Bou J, Beleta J, Doménech T, Ryder H, Segarra V, Palacios JM.
Bioorg Med Chem Lett (2000) 10 : 2661 -2664
PubMed 11128646 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.43 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89121 1 5.00
CHEMBL86888 1 4.60
CHEMBL314089 1 4.58
CHEMBL90335 1 4.51
CHEMBL88155 1 4.32
CHEMBL90289 1 4.17
CHEMBL89202 1 4.17
CHEMBL91952 1 4.07
CHEMBL330315 1 -
CHEMBL90888 1 -
CHEMBL63 ROLIPRAM 2.0 1 -
CHEMBL88990 NITRAQUAZONE 2.0 1 -
CHEMBL315657 1 -
CHEMBL314537 1 -
CHEMBL314088 1 -
CHEMBL315764 1 -
CHEMBL88853 1 -
CHEMBL90920 1 -
CHEMBL90189 1 -
CHEMBL88527 1 -
CHEMBL91007 1 -
CHEMBL314734 1 -
CHEMBL327581 1 -
CHEMBL92004 1 -
CHEMBL316449 1 -
CHEMBL88442 1 -
CHEMBL3144657 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89121 IC50 = 10000.0 nM 5.00
CHEMBL86888 IC50 = 25000.0 nM 4.60
CHEMBL314089 IC50 = 26000.0 nM 4.58
CHEMBL90335 IC50 = 31000.0 nM 4.51
CHEMBL88155 IC50 = 48000.0 nM 4.32
CHEMBL90289 IC50 = 68000.0 nM 4.17
CHEMBL89202 IC50 = 67000.0 nM 4.17
CHEMBL91952 IC50 = 86000.0 nM 4.07
CHEMBL330315 IC50 > 100000.0 nM -
CHEMBL90888 IC50 > 200000.0 nM -
CHEMBL63 ROLIPRAM IC50 = 242000.0 nM -
CHEMBL88990 NITRAQUAZONE IC50 > 200000.0 nM -
CHEMBL315657 IC50 > 20000.0 nM -
CHEMBL314537 IC50 = 111000.0 nM -
CHEMBL314088 IC50 > 20000.0 nM -
CHEMBL315764 IC50 = 120000.0 nM -
CHEMBL88853 IC50 > 200000.0 nM -
CHEMBL90920 IC50 > 20000.0 nM -
CHEMBL90189 IC50 > 20000.0 nM -
CHEMBL88527 IC50 > 20000.0 nM -
CHEMBL91007 IC50 > 200000.0 nM -
CHEMBL314734 IC50 = 102000.0 nM -
CHEMBL327581 IC50 > 20000.0 nM -
CHEMBL92004 IC50 > 20000.0 nM -
CHEMBL316449 IC50 > 20000.0 nM -
CHEMBL88442 IC50 > 100000.0 nM -
CHEMBL3144657 IC50 = 136000.0 nM -