Assay Detail
Binding
CHEMBL761609
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Inhibition of human recombinant Poly (ADP-ribose) polymerase 1
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444846 | — | — | 1 | 7.70 |
| CHEMBL84096 | — | — | 1 | 7.60 |
| CHEMBL83224 | — | — | 1 | 7.52 |
| CHEMBL310320 | — | — | 1 | 7.51 |
| CHEMBL84371 | — | — | 1 | 7.50 |
| CHEMBL84979 | — | — | 1 | 7.46 |
| CHEMBL84741 | — | — | 1 | 7.38 |
| CHEMBL84192 | — | — | 1 | 7.23 |
| CHEMBL310120 | — | — | 1 | 7.05 |
| CHEMBL82336 | — | — | 1 | 7.00 |
| CHEMBL312316 | — | — | 1 | 6.94 |
| CHEMBL82342 | — | — | 1 | 6.89 |
| CHEMBL84886 | — | — | 1 | 6.79 |
| CHEMBL83760 | — | — | 1 | 6.78 |
| CHEMBL311091 | — | — | 1 | 6.77 |
| CHEMBL85733 | — | — | 1 | 6.73 |
| CHEMBL84265 | — | — | 1 | 6.68 |
| CHEMBL309636 | — | — | 1 | 6.62 |
| CHEMBL420964 | — | — | 1 | 6.61 |
| CHEMBL45245 | — | — | 1 | 6.46 |
| CHEMBL83432 | — | — | 1 | 6.46 |
| CHEMBL82940 | — | — | 1 | 6.45 |
| CHEMBL313782 | — | — | 1 | 6.42 |
| CHEMBL312183 | — | — | 1 | 6.34 |
| CHEMBL84044 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444846 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL84096 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL83224 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL310320 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL84371 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL84979 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL84741 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL84192 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL310120 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL82336 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL312316 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL82342 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL84886 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL83760 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL311091 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL85733 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL84265 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL309636 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL420964 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL45245 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL83432 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL82940 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL313782 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL312183 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL84044 | — | IC50 | = | 7500.0 | nM | 5.12 |