Assay Detail
Binding
CHEMBL761610
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Inhibitory activity against Poly (ADP-ribose) polymerase 1
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.63 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160877 | — | — | 1 | 7.38 |
| CHEMBL105995 | — | — | 1 | 7.35 |
| CHEMBL107659 | — | — | 1 | 7.29 |
| CHEMBL107284 | — | — | 1 | 7.24 |
| CHEMBL108431 | — | — | 1 | 7.15 |
| CHEMBL543394 | — | — | 1 | 7.12 |
| CHEMBL558796 | — | — | 1 | 7.07 |
| CHEMBL543157 | — | — | 1 | 7.01 |
| CHEMBL543159 | — | — | 1 | 6.96 |
| CHEMBL418813 | — | — | 1 | 6.95 |
| CHEMBL320031 | — | — | 1 | 6.94 |
| CHEMBL82342 | — | — | 1 | 6.89 |
| CHEMBL542692 | — | — | 1 | 6.87 |
| CHEMBL545507 | — | — | 1 | 6.85 |
| CHEMBL542927 | — | — | 1 | 6.82 |
| CHEMBL541576 | — | — | 1 | 6.78 |
| CHEMBL311091 | — | — | 1 | 6.77 |
| CHEMBL108106 | — | — | 1 | 6.76 |
| CHEMBL106154 | — | — | 1 | 6.75 |
| CHEMBL106734 | — | — | 1 | 6.68 |
| CHEMBL106298 | — | — | 1 | 6.61 |
| CHEMBL543393 | — | — | 1 | 6.56 |
| CHEMBL110381 | — | — | 1 | 6.51 |
| CHEMBL107709 | — | — | 1 | 6.47 |
| CHEMBL45245 | — | — | 1 | 6.46 |
| CHEMBL323384 | — | — | 1 | 6.11 |
| CHEMBL108849 | — | — | 1 | 5.58 |
| CHEMBL109064 | — | — | 1 | 5.54 |
| CHEMBL107738 | — | — | 1 | 4.85 |
| CHEMBL267373 | BENZAMIDE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160877 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL105995 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL107659 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL107284 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL108431 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL543394 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL558796 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL543157 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL543159 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL418813 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL320031 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL82342 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL542692 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL545507 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL542927 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL541576 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL311091 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL108106 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL106154 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL106734 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL106298 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL543393 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL110381 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL107709 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL45245 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL323384 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL108849 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL109064 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL107738 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL267373 | BENZAMIDE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 210000.0 | nM | - |