Assay Detail
Binding
CHEMBL761611
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Inhibitory concentration against purified recombinant human Poly (ADP-ribose) polymerase 1
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46137 | — | — | 1 | 8.00 |
| CHEMBL47508 | — | — | 1 | 7.85 |
| CHEMBL298053 | — | — | 1 | 7.68 |
| CHEMBL540525 | — | — | 1 | 7.52 |
| CHEMBL47283 | — | — | 1 | 7.48 |
| CHEMBL296032 | — | — | 1 | 7.46 |
| CHEMBL417002 | — | — | 1 | 7.44 |
| CHEMBL46196 | — | — | 1 | 7.43 |
| CHEMBL48138 | — | — | 1 | 7.24 |
| CHEMBL296750 | — | — | 1 | 7.04 |
| CHEMBL47371 | — | — | 1 | 6.87 |
| CHEMBL289834 | — | — | 1 | 6.82 |
| CHEMBL48391 | — | — | 1 | 6.81 |
| CHEMBL225725 | — | — | 1 | 6.75 |
| CHEMBL45764 | — | — | 1 | 6.75 |
| CHEMBL294995 | — | — | 1 | 6.74 |
| CHEMBL297175 | — | — | 1 | 6.71 |
| CHEMBL298450 | — | — | 1 | 6.62 |
| CHEMBL298064 | — | — | 1 | 6.51 |
| CHEMBL45245 | — | — | 1 | 6.28 |
| CHEMBL45072 | — | — | 1 | 5.70 |
| CHEMBL47840 | — | — | 1 | 5.49 |
| CHEMBL45904 | — | — | 1 | 5.21 |
| CHEMBL297200 | — | — | 1 | 4.85 |
| CHEMBL47846 | — | — | 1 | 4.46 |
| CHEMBL44692 | — | — | 1 | - |
| CHEMBL46267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46137 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL47508 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL298053 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL540525 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL47283 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL296032 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL417002 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL46196 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL48138 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL296750 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL47371 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL289834 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL48391 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL225725 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL45764 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL294995 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL297175 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL298450 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL298064 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL45245 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL45072 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL47840 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL45904 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL297200 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL47846 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL44692 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL46267 | — | IC50 | > | 100000.0 | nM | - |