Assay Detail
Functional
CHEMBL761664
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Antagonism of calmodulin dependent cAMP Phosphodiesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-Substituted analogues of idoxifene: Antiestrogens and calmodulin antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6318 | IDOXIFENE | 2.0 | 1 | 5.82 |
| CHEMBL167875 | — | — | 1 | 5.75 |
| CHEMBL354660 | — | — | 1 | 5.66 |
| CHEMBL353485 | — | — | 1 | 5.58 |
| CHEMBL167821 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6318 | IDOXIFENE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL167875 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL354660 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL353485 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL167821 | — | IC50 | = | 5000.0 | nM | 5.30 |