Assay Detail
Binding
CHEMBL761830
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Inhibitory activity against bovine PDE5 (phosphodiesterase-5).
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141631 | — | — | 1 | 8.52 |
| CHEMBL141918 | — | — | 1 | 8.40 |
| CHEMBL337587 | — | — | 1 | 8.30 |
| CHEMBL140874 | — | — | 1 | 8.22 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.22 |
| CHEMBL138658 | — | — | 1 | 8.15 |
| CHEMBL334910 | — | — | 1 | 8.15 |
| CHEMBL422104 | — | — | 1 | 8.10 |
| CHEMBL344173 | — | — | 1 | 8.00 |
| CHEMBL140828 | — | — | 1 | 8.00 |
| CHEMBL343832 | — | — | 1 | 7.75 |
| CHEMBL344630 | — | — | 1 | 7.70 |
| CHEMBL336457 | — | — | 1 | 7.70 |
| CHEMBL138256 | — | — | 1 | 7.70 |
| CHEMBL337770 | — | — | 1 | 7.70 |
| CHEMBL141577 | — | — | 1 | 7.52 |
| CHEMBL335148 | — | — | 1 | 7.52 |
| CHEMBL141633 | — | — | 1 | 7.30 |
| CHEMBL139048 | — | — | 1 | 7.30 |
| CHEMBL502020 | — | — | 1 | 7.30 |
| CHEMBL423550 | — | — | 1 | 7.22 |
| CHEMBL140493 | — | — | 1 | 7.05 |
| CHEMBL141980 | — | — | 1 | 7.00 |
| CHEMBL344676 | — | — | 1 | 7.00 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.70 |
| CHEMBL2110369 | — | — | 1 | 6.52 |
| CHEMBL141506 | — | — | 1 | 6.52 |
| CHEMBL11709 | — | — | 1 | 6.10 |
| CHEMBL141975 | — | — | 1 | 6.05 |
| CHEMBL504118 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141631 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL141918 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL337587 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL140874 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL138658 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL334910 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL422104 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL344173 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL140828 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL343832 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL344630 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL336457 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL138256 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL337770 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL335148 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL141577 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL141633 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL139048 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL502020 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL423550 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL140493 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL141980 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL344676 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2110369 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL141506 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL11709 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL141975 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL504118 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL138359 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL140605 | — | IC50 | > | 10000.0 | nM | - |