Assay Detail
Binding
CHEMBL761835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine arterial Phosphodiesterase 5
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.66 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103976 | — | — | 1 | 8.00 |
| CHEMBL319217 | — | — | 1 | 7.34 |
| CHEMBL102807 | — | — | 1 | 6.00 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.30 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103976 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL319217 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL102807 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL189 | MILRINONE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |