Assay Detail
Binding
CHEMBL761874
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Inhibition of protein kinase C epsilon
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265559 | — | — | 1 | 8.00 |
| CHEMBL49354 | — | — | 2 | 7.70 |
| CHEMBL48636 | — | — | 1 | 7.30 |
| CHEMBL295806 | — | — | 2 | 6.92 |
| CHEMBL48988 | — | — | 1 | 6.62 |
| CHEMBL300422 | — | — | 1 | 5.75 |
| CHEMBL48546 | — | — | 1 | 5.40 |
| CHEMBL48665 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265559 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL49354 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL49354 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL48636 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL295806 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL48988 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL295806 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL300422 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL48546 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL48665 | — | IC50 | = | 4500.0 | nM | 5.35 |