Assay Detail

CHEMBL761994

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HIV-1 strain LAI in PBM cells on day 6

ChEMBL ↗

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Target

PBMC (CHEMBL613107) ↗

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Primary target PBMC

CHEMBL613107

Anchored from Assay target.

Protein identity PBMC

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PBMC
Confidence	1 — Organism
Curated By	Intermediate

Target

PBMC (CHEMBL613107) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.

Fulcrand-el Kattan G, Goudgaon NM, Ilksoy N, Huang JT, Watanabe KA, Sommadossi JP, Schinazi RF.
J Med Chem (1994) 37 : 2583 -2588
PubMed 8057301 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.27	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL129	ZIDOVUDINE	4.0	1	8.40
CHEMBL3142561	—	—	1	4.13

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL129	ZIDOVUDINE	EC50	=	4.0	nM	8.40
CHEMBL3142561	—	EC50	=	73200.0	nM	4.13