Assay Detail
Functional
CHEMBL762017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.21 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | 2.0 | 2 | 7.68 |
| CHEMBL1630 | — | — | 1 | 7.57 |
| CHEMBL138786 | — | — | 1 | 7.13 |
| CHEMBL337981 | FLOUROTEBUQUINE | — | 1 | 7.13 |
| CHEMBL335121 | — | — | 1 | 6.99 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL1630 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL339049 | TEBUQUINE | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL138786 | — | IC50 | = | 74.2 | nM | 7.13 |
| CHEMBL337981 | FLOUROTEBUQUINE | IC50 | = | 74.3 | nM | 7.13 |
| CHEMBL335121 | — | IC50 | = | 101.3 | nM | 6.99 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 250.0 | nM | 6.60 |