Assay Detail
Functional
CHEMBL762018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.85 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | 2.0 | 2 | 9.05 |
| CHEMBL141682 | — | — | 1 | 8.77 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | — | 1 | 8.43 |
| CHEMBL1630 | — | — | 1 | 8.43 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 8.35 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.01 |
| CHEMBL138623 | — | — | 1 | 7.79 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 7.77 |
| CHEMBL283888 | — | — | 1 | 7.50 |
| CHEMBL30209 | — | — | 1 | 7.33 |
| CHEMBL285099 | — | — | 1 | 7.26 |
| CHEMBL138786 | — | — | 1 | 7.25 |
| CHEMBL337981 | FLOUROTEBUQUINE | — | 1 | 7.21 |
| CHEMBL335121 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL141682 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1630 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 9.75 | nM | 8.01 |
| CHEMBL138623 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL339049 | TEBUQUINE | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL283888 | — | IC50 | = | 31.9 | nM | 7.50 |
| CHEMBL30209 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL285099 | — | IC50 | = | 55.2 | nM | 7.26 |
| CHEMBL138786 | — | IC50 | = | 56.6 | nM | 7.25 |
| CHEMBL337981 | FLOUROTEBUQUINE | IC50 | = | 61.6 | nM | 7.21 |
| CHEMBL335121 | — | IC50 | = | 104.1 | nM | 6.98 |