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Assay Detail

CHEMBL762020

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum FcB1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin.
Grellepois F, Chorki F, Ourévitch M, Charneau S, Grellier P, McIntosh KA, Charman WN, Pradines B, Crousse B, Bonnet-Delpon D, Bégué JP.
J Med Chem (2004) 47 : 1423 -1433
PubMed 14998331 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.27 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3038030 1 8.92
CHEMBL3038036 1 8.77
CHEMBL3038035 1 8.62
CHEMBL3038038 1 8.57
CHEMBL3038029 1 8.51
CHEMBL566534 ARTEMETHER 4.0 1 8.46
CHEMBL3038026 1 8.43
CHEMBL3038042 1 8.36
CHEMBL3038032 1 8.22
CHEMBL3038037 1 8.22
CHEMBL3038027 1 8.12
CHEMBL3038043 1 8.04
CHEMBL3038044 1 8.00
CHEMBL3038040 1 7.72
CHEMBL520530 ANHYDRODIHYDROARTEMISININ 1 7.70
CHEMBL3038041 1 7.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3038030 IC50 = 1.2 nM 8.92
CHEMBL3038036 IC50 = 1.7 nM 8.77
CHEMBL3038035 IC50 = 2.4 nM 8.62
CHEMBL3038038 IC50 = 2.7 nM 8.57
CHEMBL3038029 IC50 = 3.1 nM 8.51
CHEMBL566534 ARTEMETHER IC50 = 3.5 nM 8.46
CHEMBL3038026 IC50 = 3.7 nM 8.43
CHEMBL3038042 IC50 = 4.4 nM 8.36
CHEMBL3038032 IC50 = 6.0 nM 8.22
CHEMBL3038037 IC50 = 6.0 nM 8.22
CHEMBL3038027 IC50 = 7.5 nM 8.12
CHEMBL3038043 IC50 = 9.2 nM 8.04
CHEMBL3038044 IC50 = 10.0 nM 8.00
CHEMBL3038040 IC50 = 19.1 nM 7.72
CHEMBL520530 ANHYDRODIHYDROARTEMISININ IC50 = 20.0 nM 7.70
CHEMBL3038041 IC50 = 20.0 nM 7.70