Assay Detail
Binding
CHEMBL762040
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Inhibition of Phosphodiesterase 4 from rat liver
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.17 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.95 |
| CHEMBL77651 | SOPHOFLAVESCENOL | — | 1 | 5.59 |
| CHEMBL455667 | KURARINOL | — | 1 | 5.18 |
| CHEMBL243362 | KURAIDIN | — | 1 | 5.08 |
| CHEMBL77703 | — | — | 1 | 4.73 |
| CHEMBL440494 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL77651 | SOPHOFLAVESCENOL | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL455667 | KURARINOL | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL243362 | KURAIDIN | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL77703 | — | IC50 | = | 18710.0 | nM | 4.73 |
| CHEMBL440494 | — | IC50 | = | 33840.0 | nM | 4.47 |