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Assay Detail

CHEMBL762050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR delta receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type COS-1
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
Adams AD, Yuen W, Hu Z, Santini C, Jones AB, MacNaul KL, Berger JP, Doebber TW, Moller DE.
Bioorg Med Chem Lett (2003) 13 : 931 -935
PubMed 12617924 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 7.07 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367019 1 8.52
CHEMBL172490 1 7.89
CHEMBL173494 1 7.80
CHEMBL435523 1 7.70
CHEMBL172959 1 6.83
CHEMBL173285 1 6.83
CHEMBL263029 1 6.76
CHEMBL175332 1 6.74
CHEMBL435715 1 6.40
CHEMBL172492 1 6.19
CHEMBL173159 1 6.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367019 EC50 = 3.0 nM 8.52
CHEMBL172490 EC50 = 13.0 nM 7.89
CHEMBL173494 EC50 = 16.0 nM 7.80
CHEMBL435523 EC50 = 20.0 nM 7.70
CHEMBL172959 EC50 = 148.0 nM 6.83
CHEMBL173285 EC50 = 147.0 nM 6.83
CHEMBL263029 EC50 = 172.0 nM 6.76
CHEMBL175332 EC50 = 183.0 nM 6.74
CHEMBL435715 EC50 = 400.0 nM 6.40
CHEMBL172492 EC50 = 640.0 nM 6.19
CHEMBL173159 EC50 = 860.0 nM 6.07