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Assay Detail

CHEMBL762152

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Binding
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
Cobb JE, Blanchard SG, Boswell EG, Brown KK, Charifson PS, Cooper JP, Collins JL, Dezube M, Henke BR, Hull-Ryde EA, Lake DH, Lenhard JM, Oliver W, Oplinger J, Pentti M, Parks DJ, Plunket KD, Tong WQ.
J Med Chem (1998) 41 : 5055 -5069
PubMed 9836622 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 43 8.02 9.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL148384 1 9.03
CHEMBL148668 1 9.01
CHEMBL107367 FARGLITAZAR 2.0 1 8.94
CHEMBL148596 1 8.83
CHEMBL2112870 1 8.79
CHEMBL147021 1 8.76
CHEMBL414442 1 8.74
CHEMBL146355 1 8.65
CHEMBL145886 1 8.64
CHEMBL146562 1 8.63
CHEMBL147770 1 8.62
CHEMBL149780 1 8.59
CHEMBL146637 1 8.58
CHEMBL146579 1 8.57
CHEMBL150215 1 8.57
CHEMBL146584 1 8.56
CHEMBL150232 1 8.55
CHEMBL148300 1 8.52
CHEMBL347788 1 8.49
CHEMBL146530 1 8.47
CHEMBL106666 GW7845 1 8.43
CHEMBL2112871 1 8.39
CHEMBL145824 1 8.38
CHEMBL146217 1 8.29
CHEMBL149381 1 8.25
CHEMBL149714 1 8.19
CHEMBL146258 1 8.06
CHEMBL345541 1 8.01
CHEMBL359333 1 7.87
CHEMBL359150 1 7.81

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL148384 Ki = 0.9333 nM 9.03
CHEMBL148668 Ki = 0.9772 nM 9.01
CHEMBL107367 FARGLITAZAR Ki = 1.148 nM 8.94
CHEMBL148596 Ki = 1.479 nM 8.83
CHEMBL2112870 Ki = 1.622 nM 8.79
CHEMBL147021 Ki = 1.738 nM 8.76
CHEMBL414442 Ki = 1.82 nM 8.74
CHEMBL146355 Ki = 2.239 nM 8.65
CHEMBL145886 Ki = 2.291 nM 8.64
CHEMBL146562 Ki = 2.344 nM 8.63
CHEMBL147770 Ki = 2.399 nM 8.62
CHEMBL149780 Ki = 2.57 nM 8.59
CHEMBL146637 Ki = 2.63 nM 8.58
CHEMBL146579 Ki = 2.692 nM 8.57
CHEMBL150215 Ki = 2.692 nM 8.57
CHEMBL146584 Ki = 2.754 nM 8.56
CHEMBL150232 Ki = 2.818 nM 8.55
CHEMBL148300 Ki = 3.02 nM 8.52
CHEMBL347788 Ki = 3.236 nM 8.49
CHEMBL146530 Ki = 3.388 nM 8.47
CHEMBL106666 GW7845 Ki = 3.715 nM 8.43
CHEMBL2112871 Ki = 4.074 nM 8.39
CHEMBL145824 Ki = 4.169 nM 8.38
CHEMBL146217 Ki = 5.129 nM 8.29
CHEMBL149381 Ki = 5.623 nM 8.25
CHEMBL149714 Ki = 6.457 nM 8.19
CHEMBL146258 Ki = 8.71 nM 8.06
CHEMBL345541 Ki = 9.772 nM 8.01
CHEMBL359333 Ki = 13.49 nM 7.87
CHEMBL359150 Ki = 15.49 nM 7.81
CHEMBL147419 Ki = 15.49 nM 7.81
CHEMBL421781 Ki = 23.44 nM 7.63
CHEMBL146821 Ki = 39.81 nM 7.40
CHEMBL342990 Ki = 42.66 nM 7.37
CHEMBL147282 Ki = 66.07 nM 7.18
CHEMBL149309 Ki = 154.88 nM 6.81
CHEMBL2112020 Ki = 190.55 nM 6.72
CHEMBL146687 Ki = 251.19 nM 6.60
CHEMBL149147 Ki = 645.65 nM 6.19
CHEMBL145938 Ki = 812.83 nM 6.09
CHEMBL344776 Ki = 1148.15 nM 5.94
CHEMBL2112021 Ki = 1548.82 nM 5.81
CHEMBL356353 Ki < 3162.28 nM -