Assay Detail
Binding
CHEMBL762185
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Inhibition of rat brain PKC kinase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 4.85 |
| CHEMBL334881 | — | — | 1 | 4.79 |
| CHEMBL133498 | — | — | 1 | - |
| CHEMBL1242973 | BUTYROLACTONE I | — | 1 | - |
| CHEMBL280074 | OLOMOUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL334881 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL133498 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1242973 | BUTYROLACTONE I | IC50 | = | 160000.0 | nM | - |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 1000000.0 | nM | - |