Assay Detail
Binding
CHEMBL762474
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Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assay
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.59 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108840 | — | — | 1 | 7.16 |
| CHEMBL108339 | — | — | 2 | 7.16 |
| CHEMBL322133 | — | — | 1 | 7.16 |
| CHEMBL108702 | — | — | 1 | 7.16 |
| CHEMBL433356 | — | — | 1 | 7.10 |
| CHEMBL323488 | — | — | 1 | 7.10 |
| CHEMBL321703 | — | — | 1 | 7.00 |
| CHEMBL108623 | — | — | 1 | 7.00 |
| CHEMBL430707 | — | — | 1 | 7.00 |
| CHEMBL107601 | — | — | 1 | 7.00 |
| CHEMBL419020 | — | — | 1 | 7.00 |
| CHEMBL108919 | — | — | 1 | 7.00 |
| CHEMBL107764 | — | — | 1 | 6.70 |
| CHEMBL110115 | — | — | 1 | 6.70 |
| CHEMBL321638 | — | — | 1 | 6.70 |
| CHEMBL107260 | — | — | 1 | 6.52 |
| CHEMBL108239 | — | — | 1 | 6.40 |
| CHEMBL108137 | — | — | 1 | 6.40 |
| CHEMBL111606 | — | — | 1 | 6.30 |
| CHEMBL108968 | — | — | 1 | 6.30 |
| CHEMBL107935 | — | — | 1 | 6.30 |
| CHEMBL108341 | — | — | 1 | 6.30 |
| CHEMBL108316 | — | — | 1 | 6.22 |
| CHEMBL410733 | — | — | 1 | 6.16 |
| CHEMBL432211 | — | — | 1 | 6.10 |
| CHEMBL421605 | — | — | 1 | 6.05 |
| CHEMBL107616 | — | — | 1 | 5.70 |
| CHEMBL322957 | — | — | 1 | 5.46 |
| CHEMBL110178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108840 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL108339 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL322133 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL108702 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL433356 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL323488 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL321703 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL108623 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL430707 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL107601 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL419020 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL108919 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL321638 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL110115 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL107764 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL107260 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL108239 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL108137 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL111606 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108968 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL107935 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108341 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108316 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL410733 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL432211 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL108339 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL421605 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL107616 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL322957 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL110178 | — | EC50 | > | 1000.0 | nM | - |