Assay Detail
Binding
CHEMBL762476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant PARP-1
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.24 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323488 | — | — | 1 | 8.07 |
| CHEMBL108919 | — | — | 1 | 7.92 |
| CHEMBL107764 | — | — | 1 | 7.92 |
| CHEMBL321638 | — | — | 1 | 7.82 |
| CHEMBL322133 | — | — | 1 | 7.82 |
| CHEMBL321703 | — | — | 1 | 7.82 |
| CHEMBL108702 | — | — | 1 | 7.70 |
| CHEMBL108239 | — | — | 1 | 7.70 |
| CHEMBL107601 | — | — | 1 | 7.70 |
| CHEMBL108341 | — | — | 1 | 7.70 |
| CHEMBL108623 | — | — | 1 | 7.70 |
| CHEMBL108339 | — | — | 2 | 7.70 |
| CHEMBL433356 | — | — | 1 | 7.60 |
| CHEMBL108840 | — | — | 1 | 7.60 |
| CHEMBL108137 | — | — | 1 | 7.60 |
| CHEMBL432211 | — | — | 1 | 7.60 |
| CHEMBL108968 | — | — | 1 | 7.52 |
| CHEMBL107935 | — | — | 1 | 7.52 |
| CHEMBL110115 | — | — | 1 | 7.52 |
| CHEMBL430707 | — | — | 1 | 7.46 |
| CHEMBL110178 | — | — | 1 | 7.40 |
| CHEMBL419020 | — | — | 1 | 7.40 |
| CHEMBL108316 | — | — | 1 | 7.30 |
| CHEMBL111606 | — | — | 1 | 7.22 |
| CHEMBL320579 | — | — | 1 | 7.22 |
| CHEMBL410733 | — | — | 1 | 7.16 |
| CHEMBL107616 | — | — | 1 | 7.16 |
| CHEMBL322957 | — | — | 1 | 7.16 |
| CHEMBL421605 | — | — | 1 | 7.10 |
| CHEMBL107260 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323488 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL108919 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL107764 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL321638 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL322133 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL321703 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL108702 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108239 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108339 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108623 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107601 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108341 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108840 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL432211 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL433356 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL108339 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL108137 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL110115 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL108968 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL107935 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL430707 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL419020 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL110178 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL108316 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL320579 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL111606 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107616 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL410733 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL322957 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL421605 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL107260 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL432406 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL322268 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL105765 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL449084 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL110681 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL105925 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL110332 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL325336 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL110729 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL110682 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL110347 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL326451 | — | IC50 | > | 5000.0 | nM | - |