Assay Detail
Binding
CHEMBL762496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Phosphodiesterase 5 activity of human corpus cavernosum
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 9.07 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744059 | — | — | 1 | 9.68 |
| CHEMBL336815 | — | — | 1 | 9.68 |
| CHEMBL130721 | — | — | 1 | 9.64 |
| CHEMBL133687 | — | — | 1 | 9.54 |
| CHEMBL131718 | — | — | 1 | 9.51 |
| CHEMBL130811 | — | — | 1 | 9.40 |
| CHEMBL131892 | — | — | 1 | 9.28 |
| CHEMBL280439 | — | — | 1 | 9.28 |
| CHEMBL132689 | — | — | 1 | 8.97 |
| CHEMBL336291 | — | — | 1 | 8.94 |
| CHEMBL341092 | — | — | 1 | 8.92 |
| CHEMBL131541 | — | — | 1 | 8.76 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.73 |
| CHEMBL133285 | — | — | 1 | 8.05 |
| CHEMBL130612 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744059 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL336815 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL130721 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL133687 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL131718 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL130811 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL131892 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL280439 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL132689 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL336291 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL341092 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL131541 | — | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL192 | SILDENAFIL | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL133285 | — | Ki | = | 8.86 | nM | 8.05 |
| CHEMBL130612 | — | Ki | = | 24.7 | nM | 7.61 |