Assay Detail
Binding
CHEMBL762497
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Inhibitory activity against PDE5 from human corpus cavernosum
31
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.14 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.73 |
| CHEMBL163905 | — | — | 1 | 8.40 |
| CHEMBL433708 | — | — | 1 | 8.09 |
| CHEMBL133285 | — | — | 1 | 8.05 |
| CHEMBL350187 | — | — | 1 | 7.75 |
| CHEMBL351744 | — | — | 1 | 7.62 |
| CHEMBL349359 | — | — | 1 | 7.49 |
| CHEMBL166018 | — | — | 1 | 7.30 |
| CHEMBL349947 | — | — | 2 | 7.20 |
| CHEMBL349204 | — | — | 1 | 7.19 |
| CHEMBL166025 | — | — | 1 | 7.11 |
| CHEMBL165117 | — | — | 1 | 6.91 |
| CHEMBL164755 | — | — | 1 | 6.90 |
| CHEMBL446433 | — | — | 1 | 6.90 |
| CHEMBL164181 | — | — | 1 | 6.89 |
| CHEMBL165168 | — | — | 1 | 6.88 |
| CHEMBL350515 | — | — | 1 | 6.84 |
| CHEMBL163890 | — | — | 1 | 6.81 |
| CHEMBL350962 | — | — | 1 | 6.75 |
| CHEMBL423088 | — | — | 2 | 6.73 |
| CHEMBL163712 | — | — | 1 | 6.66 |
| CHEMBL164906 | — | — | 2 | 6.61 |
| CHEMBL349495 | — | — | 1 | 6.26 |
| CHEMBL350400 | — | — | 1 | 6.07 |
| CHEMBL433528 | — | — | 1 | - |
| CHEMBL165110 | — | — | 1 | - |
| CHEMBL166157 | — | — | 1 | - |
| CHEMBL164907 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL163905 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL433708 | — | Ki | = | 8.11 | nM | 8.09 |
| CHEMBL133285 | — | Ki | = | 8.86 | nM | 8.05 |
| CHEMBL350187 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL351744 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL349359 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL166018 | — | Ki | = | 50.6 | nM | 7.30 |
| CHEMBL349947 | — | Ki | = | 62.8 | nM | 7.20 |
| CHEMBL349947 | — | Ki | = | 62.8 | nM | 7.20 |
| CHEMBL349204 | — | Ki | = | 64.2 | nM | 7.19 |
| CHEMBL166025 | — | Ki | = | 77.5 | nM | 7.11 |
| CHEMBL165117 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL164755 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL446433 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL164181 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL165168 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL350515 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL163890 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL350962 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL423088 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL423088 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL163712 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL164906 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL164906 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL349495 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL350400 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL433528 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL166157 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL165110 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL164907 | — | Ki | > | 100.0 | nM | - |