Assay Detail
Binding
CHEMBL762502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.50 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542166 | — | — | 1 | 9.52 |
| CHEMBL545472 | — | — | 1 | 9.49 |
| CHEMBL544305 | — | — | 1 | 9.30 |
| CHEMBL553075 | — | — | 1 | 9.28 |
| CHEMBL553960 | — | — | 1 | 9.26 |
| CHEMBL542418 | — | — | 1 | 9.15 |
| CHEMBL545715 | — | — | 1 | 9.15 |
| CHEMBL545012 | — | — | 1 | 9.15 |
| CHEMBL545243 | — | — | 1 | 9.14 |
| CHEMBL542663 | — | — | 1 | 9.10 |
| CHEMBL557200 | — | — | 1 | 9.07 |
| CHEMBL553348 | — | — | 1 | 9.03 |
| CHEMBL555168 | — | — | 1 | 9.02 |
| CHEMBL543130 | — | — | 1 | 8.96 |
| CHEMBL544548 | — | — | 1 | 8.92 |
| CHEMBL554047 | — | — | 1 | 8.91 |
| CHEMBL545476 | — | — | 1 | 8.82 |
| CHEMBL540044 | — | — | 1 | 8.77 |
| CHEMBL553076 | — | — | 1 | 8.72 |
| CHEMBL541830 | — | — | 1 | 8.70 |
| CHEMBL1737 | SILDENAFIL CITRATE | 4.0 | 1 | 8.66 |
| CHEMBL556618 | — | — | 1 | 8.59 |
| CHEMBL544310 | — | — | 1 | 8.57 |
| CHEMBL545242 | — | — | 1 | 8.52 |
| CHEMBL554459 | — | — | 1 | 8.51 |
| CHEMBL25616 | — | — | 1 | 8.43 |
| CHEMBL539789 | — | — | 1 | 8.36 |
| CHEMBL552689 | — | — | 1 | 8.17 |
| CHEMBL544546 | — | — | 1 | 8.17 |
| CHEMBL558019 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542166 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL545472 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL544305 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL553075 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL553960 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL542418 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL545715 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL545012 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL545243 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL542663 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL557200 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL553348 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL555168 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL543130 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL544548 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL554047 | — | IC50 | = | 1.23 | nM | 8.91 |
| CHEMBL545476 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL540044 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL553076 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL541830 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1737 | SILDENAFIL CITRATE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL556618 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL544310 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL545242 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL554459 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL25616 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL539789 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL552689 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL544546 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL558019 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3084583 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL544540 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL542899 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL545470 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL552862 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL553934 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL189 | MILRINONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | > | 100000.0 | nM | - |