Assay Detail
Binding
CHEMBL762508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 5 of rabbit platelets
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.37 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245317 | — | — | 1 | 9.77 |
| CHEMBL245517 | — | — | 1 | 9.74 |
| CHEMBL63548 | — | — | 1 | 9.55 |
| CHEMBL541468 | — | — | 1 | 9.55 |
| CHEMBL67064 | — | — | 1 | 9.54 |
| CHEMBL245315 | — | — | 1 | 9.52 |
| CHEMBL245323 | — | — | 1 | 9.49 |
| CHEMBL394040 | — | — | 1 | 9.47 |
| CHEMBL245522 | — | — | 1 | 9.39 |
| CHEMBL63686 | — | — | 1 | 9.24 |
| CHEMBL245922 | — | — | 1 | 9.15 |
| CHEMBL245721 | — | — | 1 | 9.03 |
| CHEMBL246536 | — | — | 1 | 8.98 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245317 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL245517 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL63548 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL541468 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL67064 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL245315 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL245323 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL394040 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL245522 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL63686 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL245922 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL245721 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL246536 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.78 | nM | 8.75 |