Assay Detail
Binding
CHEMBL762509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 5 from rabbit platelets
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.95 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444046 | — | — | 1 | 8.68 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.44 |
| CHEMBL910 | — | — | 1 | 8.24 |
| CHEMBL53538 | LODENAFIL | -1.0 | 1 | 7.72 |
| CHEMBL54079 | — | — | 1 | 7.57 |
| CHEMBL52245 | — | — | 1 | 6.11 |
| CHEMBL52141 | — | — | 1 | 6.02 |
| CHEMBL300416 | — | — | 1 | 6.00 |
| CHEMBL52072 | — | — | 1 | 5.36 |
| CHEMBL431544 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444046 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL910 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL53538 | LODENAFIL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL54079 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL52245 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL52141 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL300416 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52072 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL431544 | — | IC50 | = | 4500.0 | nM | 5.35 |