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Assay Detail

CHEMBL762589

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Functional
Cotransfection activity of compound against human Peroxisome proliferator activated receptor delta was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Xu Y, Mayhugh D, Saeed A, Wang X, Thompson RC, Dominianni SJ, Kauffman RF, Singh J, Bean JS, Bensch WR, Barr RJ, Osborne J, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Huang N, Luffer-Atlas D, Rungta D, Maise DE, Mantlo NB.
J Med Chem (2003) 46 : 5121 -5124
PubMed 14613314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 4 5.53 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL344282 1 5.54
CHEMBL149676 1 5.52
CHEMBL148639 1 5.52
CHEMBL149438 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL344282 EC50 = 2900.0 nM 5.54
CHEMBL149676 EC50 = 3000.0 nM 5.52
CHEMBL148639 EC50 = 3000.0 nM 5.52
CHEMBL149438 EC50 = 3000.0 nM 5.52