Assay Detail
Functional
CHEMBL762598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PGE-2 production in 3T3 (murine fibroblast) cell culture.
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Prostaglandin G/H synthase (cyclooxygenase) (CHEMBL2111349) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.74 | 7.70 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.70 |
| CHEMBL83990 | — | — | 1 | 7.10 |
| CHEMBL85776 | — | — | 1 | 6.96 |
| CHEMBL84785 | — | — | 1 | 6.92 |
| CHEMBL313428 | — | — | 1 | 6.72 |
| CHEMBL82325 | — | — | 1 | 6.68 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 6.66 |
| CHEMBL84670 | — | — | 1 | 6.62 |
| CHEMBL84599 | — | — | 1 | 6.34 |
| CHEMBL82292 | — | — | 1 | 6.28 |
| CHEMBL85455 | — | — | 1 | 6.12 |
| CHEMBL86214 | — | — | 1 | - |
| CHEMBL310794 | — | — | 1 | - |
| CHEMBL315801 | — | — | 1 | - |
| CHEMBL83425 | — | — | 1 | - |
| CHEMBL314856 | — | — | 1 | - |
| CHEMBL82680 | — | — | 1 | - |
| CHEMBL2114190 | — | — | 1 | - |
| CHEMBL312837 | — | — | 1 | - |
| CHEMBL83482 | — | — | 1 | - |
| CHEMBL431007 | — | — | 1 | - |
| CHEMBL315944 | — | — | 1 | - |
| CHEMBL85113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL83990 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL85776 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL84785 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL313428 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL82325 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL84670 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL84599 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL82292 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL85455 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL86214 | — | Inhibition | = | 47.0 | % | - |
| CHEMBL310794 | — | Inhibition | = | 86.0 | % | - |
| CHEMBL315801 | — | Inhibition | = | 62.0 | % | - |
| CHEMBL83425 | — | Inhibition | = | 73.0 | % | - |
| CHEMBL314856 | — | Inhibition | = | 53.0 | % | - |
| CHEMBL82680 | — | Inhibition | = | 60.0 | % | - |
| CHEMBL2114190 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL312837 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL83482 | — | Inhibition | = | 47.0 | % | - |
| CHEMBL431007 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL315944 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL85113 | — | Inhibition | = | 45.0 | % | - |