Assay Detail
Binding
CHEMBL762676
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Inhibition of low Km cAMP phosphodiesterase PDE III of human platelets
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347523 | — | — | 1 | 7.14 |
| CHEMBL799 | CILOSTAZOL | 4.0 | 1 | 6.72 |
| CHEMBL151056 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347523 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL151056 | — | IC50 | > | 500000.0 | nM | - |