Assay Detail
Binding
CHEMBL762677
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Binding affinity for low Km cAMP phosphodiesterase PDE III of human platelets
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.08 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 8.30 |
| CHEMBL153427 | OXAGRELATE | 2.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34431 | CILOSTAMIDE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL153427 | OXAGRELATE | Ki | = | 1400.0 | nM | 5.85 |