Assay Detail

CHEMBL762700

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Functional

Inhibition of PC3 cell proliferation

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

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Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Expert

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL.
J Med Chem (2002) 45 : 5233 -5248
PubMed 12431051 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.16	6.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL151546	—	—	1	6.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL151546	—	IC50	=	690.0	nM	6.16