Assay Detail
Binding
CHEMBL762736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation by human PPAR gamma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylacetic acid derivatives as hPPAR agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.50 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278994 | L-796449 | — | 1 | 8.05 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 8.00 |
| CHEMBL23874 | — | — | 1 | 7.82 |
| CHEMBL279053 | L-165461 | — | 1 | 7.72 |
| CHEMBL23296 | — | — | 1 | 7.64 |
| CHEMBL25710 | — | — | 1 | 7.16 |
| CHEMBL23670 | — | — | 1 | 6.99 |
| CHEMBL23881 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278994 | L-796449 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL23874 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL279053 | L-165461 | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL23296 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL25710 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL23670 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL23881 | — | EC50 | = | 230.0 | nM | 6.64 |