Assay Detail
Binding
CHEMBL762737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activation of human peroxisome proliferator activated receptor gamma (PPAR gamma)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.89 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.80 |
| CHEMBL86658 | — | — | 1 | 6.77 |
| CHEMBL328455 | — | — | 1 | 6.52 |
| CHEMBL672 | FENOFIBRATE | 4.0 | 1 | 6.24 |
| CHEMBL24038 | RAGAGLITAZAR | 2.0 | 1 | 6.24 |
| CHEMBL420973 | — | — | 1 | 6.22 |
| CHEMBL87928 | — | — | 1 | 6.10 |
| CHEMBL87307 | — | — | 1 | 6.05 |
| CHEMBL89152 | — | — | 1 | 5.82 |
| CHEMBL421729 | — | — | 1 | 5.77 |
| CHEMBL89996 | — | — | 1 | 5.70 |
| CHEMBL328099 | — | — | 1 | 5.66 |
| CHEMBL314483 | — | — | 1 | 5.57 |
| CHEMBL86817 | — | — | 1 | 5.54 |
| CHEMBL87380 | — | — | 1 | 5.51 |
| CHEMBL86657 | — | — | 1 | 5.48 |
| CHEMBL315048 | — | — | 1 | 5.40 |
| CHEMBL86688 | — | — | 1 | 5.37 |
| CHEMBL327481 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL86658 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL328455 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL672 | FENOFIBRATE | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL24038 | RAGAGLITAZAR | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL420973 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL87928 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL87307 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL89152 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL421729 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL89996 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328099 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL314483 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL86817 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL87380 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL86657 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL315048 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL86688 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL327481 | — | EC50 | = | 8500.0 | nM | 5.07 |