Assay Detail
Functional
CHEMBL762741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor gamma expressed in KRP-297 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KRP-297 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.53 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120009 | — | — | 1 | 6.40 |
| CHEMBL24458 | — | — | 1 | 6.10 |
| CHEMBL122070 | — | — | 1 | 5.62 |
| CHEMBL331206 | — | — | 1 | 5.60 |
| CHEMBL325723 | — | — | 1 | 5.55 |
| CHEMBL120744 | — | — | 1 | 5.55 |
| CHEMBL118483 | — | — | 1 | 5.52 |
| CHEMBL122009 | — | — | 1 | 5.52 |
| CHEMBL119791 | — | — | 1 | 5.40 |
| CHEMBL118279 | — | — | 1 | 5.27 |
| CHEMBL116947 | — | — | 1 | 5.21 |
| CHEMBL331469 | — | — | 1 | 5.13 |
| CHEMBL118198 | — | — | 1 | 5.00 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | - |
| CHEMBL118939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120009 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL24458 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL122070 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL331206 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL325723 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL120744 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL118483 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL122009 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119791 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118279 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL116947 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL331469 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL118198 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | > | 137000.0 | nM | - |
| CHEMBL118939 | — | EC50 | > | 10000.0 | nM | - |