Assay Detail
Binding
CHEMBL762789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PGH synthase in tissues with lower lipid peroxide concentrations
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Tissue | Lower lip |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogues of phenylbutazone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101 | PHENYLBUTAZONE | 4.0 | 1 | 5.00 |
| CHEMBL442026 | — | — | 1 | - |
| CHEMBL136373 | — | — | 1 | - |
| CHEMBL439611 | — | — | 1 | - |
| CHEMBL136624 | — | — | 1 | - |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | - |
| CHEMBL415726 | — | — | 1 | - |
| CHEMBL344038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101 | PHENYLBUTAZONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL442026 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL136373 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL439611 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL136624 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL112 | ACETAMINOPHEN | IC50 | > | 500000.0 | nM | - |
| CHEMBL415726 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL344038 | — | IC50 | = | 190000.0 | nM | - |