Assay Detail
Binding
CHEMBL762820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5 from human platelets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel, potent and selective PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.78 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80004 | — | — | 1 | 9.51 |
| CHEMBL309849 | — | — | 1 | 9.05 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.80 |
| CHEMBL81285 | — | — | 1 | 8.77 |
| CHEMBL79579 | — | — | 1 | 8.68 |
| CHEMBL76827 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80004 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL309849 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL81285 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL79579 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL76827 | — | IC50 | = | 13.0 | nM | 7.89 |