Assay Detail
Binding
CHEMBL762822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 5 from human platelets
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.76 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38735 | — | — | 1 | 10.30 |
| CHEMBL291127 | — | — | 1 | 9.40 |
| CHEMBL289047 | — | — | 1 | 9.32 |
| CHEMBL39065 | — | — | 1 | 9.26 |
| CHEMBL41083 | — | — | 1 | 9.22 |
| CHEMBL442348 | — | — | 1 | 8.89 |
| CHEMBL41236 | — | — | 1 | 8.85 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.80 |
| CHEMBL40371 | — | — | 1 | 8.40 |
| CHEMBL42869 | — | — | 1 | 7.14 |
| CHEMBL41950 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38735 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL291127 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL289047 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL39065 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL41083 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL442348 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL41236 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL40371 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL42869 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL41950 | — | IC50 | = | 160.0 | nM | 6.80 |