Assay Detail
Binding
CHEMBL762823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 5 from human corpus cavernosum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.52 |
| CHEMBL54079 | — | — | 1 | 7.57 |
| CHEMBL298535 | — | — | 1 | 7.09 |
| CHEMBL51814 | — | — | 1 | 6.48 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL54079 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL298535 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL51814 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 2000.0 | nM | 5.70 |