Assay Detail
Binding
CHEMBL762826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 5 from human platelets
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.37 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410215 | — | — | 1 | 10.52 |
| CHEMBL344018 | — | — | 1 | 10.00 |
| CHEMBL139998 | — | — | 1 | 9.52 |
| CHEMBL266960 | — | — | 1 | 9.22 |
| CHEMBL140520 | — | — | 1 | 9.15 |
| CHEMBL1520 | VARDENAFIL | 4.0 | 1 | 9.15 |
| CHEMBL7868 | — | — | 1 | 9.10 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.89 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410215 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL344018 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL139998 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL266960 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL140520 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1520 | VARDENAFIL | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL7868 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL779 | TADALAFIL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.6 | nM | 8.80 |