Assay Detail
Binding
CHEMBL762827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against phosphodiesterase 5 (PDE5) from human platelet
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.96 |
| CHEMBL100779 | — | — | 1 | 6.57 |
| CHEMBL516604 | — | — | 1 | 5.52 |
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 5.15 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL100779 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL516604 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL34431 | CILOSTAMIDE | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |
| CHEMBL313842 | ZARDAVERINE | IC50 | > | 10000.0 | nM | - |