Assay Detail
Binding
CHEMBL762828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 5
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.32 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168949 | — | — | 1 | 9.22 |
| CHEMBL1339 | VARDENAFIL HYDROCHLORIDE | 4.0 | 1 | 9.15 |
| CHEMBL352722 | — | — | 1 | 8.30 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.18 |
| CHEMBL169843 | — | — | 1 | 8.00 |
| CHEMBL353248 | — | — | 1 | 8.00 |
| CHEMBL54079 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168949 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1339 | VARDENAFIL HYDROCHLORIDE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL352722 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL169843 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL353248 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL54079 | — | IC50 | = | 40.0 | nM | 7.40 |