Assay Detail
Binding
CHEMBL762829
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Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86512 | — | — | 1 | 8.52 |
| CHEMBL314849 | — | — | 1 | 8.46 |
| CHEMBL327772 | — | — | 1 | 8.46 |
| CHEMBL433418 | — | — | 1 | 8.30 |
| CHEMBL315477 | — | — | 1 | 8.26 |
| CHEMBL89248 | — | — | 1 | 8.05 |
| CHEMBL87202 | — | — | 2 | 8.00 |
| CHEMBL90164 | — | — | 1 | 7.96 |
| CHEMBL89670 | — | — | 1 | 7.92 |
| CHEMBL89239 | — | — | 1 | 7.80 |
| CHEMBL86785 | — | — | 1 | 7.80 |
| CHEMBL314891 | — | — | 1 | 7.72 |
| CHEMBL85350 | — | — | 1 | 7.70 |
| CHEMBL313197 | — | — | 1 | 7.62 |
| CHEMBL89151 | — | — | 1 | 7.58 |
| CHEMBL87304 | — | — | 1 | 7.55 |
| CHEMBL84731 | — | — | 1 | 7.23 |
| CHEMBL87901 | — | — | 1 | 7.22 |
| CHEMBL86673 | — | — | 1 | 7.20 |
| CHEMBL410057 | — | — | 1 | 7.14 |
| CHEMBL314667 | — | — | 1 | 7.11 |
| CHEMBL86743 | — | — | 1 | 7.04 |
| CHEMBL86578 | — | — | 1 | 7.03 |
| CHEMBL86602 | — | — | 1 | 7.00 |
| CHEMBL87777 | — | — | 1 | 7.00 |
| CHEMBL316372 | — | — | 1 | 6.98 |
| CHEMBL313561 | — | — | 1 | 6.89 |
| CHEMBL87954 | — | — | 1 | 6.87 |
| CHEMBL313482 | — | — | 1 | 6.80 |
| CHEMBL314981 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86512 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL314849 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL327772 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL433418 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL315477 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL89248 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL87202 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL87202 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL90164 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL89670 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL86785 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL89239 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL314891 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL85350 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL313197 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL89151 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL87304 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL84731 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL87901 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL86673 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL410057 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL314667 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL86743 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL86578 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL86602 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL87777 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL316372 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL313561 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL87954 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL313482 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL314981 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL86982 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL420599 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL327666 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL316209 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL85230 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL87925 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421163 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL87106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86501 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL316185 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89381 | — | IC50 | > | 10000.0 | nM | - |