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Assay Detail

CHEMBL762906

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration required to inhibit human Prostaglandin G/H synthase 2 (COX-2) by 50%
ChEMBL ↗
96
Total Activities
96
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 2 (CHEMBL230) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC.
J Med Chem (1997) 40 : 1634 -1647
PubMed 9171873 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 96 6.67 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298476 — — 1 8.52
CHEMBL46584 — — 1 8.15
CHEMBL298269 — — 1 8.10
CHEMBL42674 — — 1 8.00
CHEMBL46623 — — 1 8.00
CHEMBL45192 — — 1 8.00
CHEMBL289561 — — 1 7.70
CHEMBL298313 — — 1 7.70
CHEMBL296662 — — 1 7.52
CHEMBL296571 — — 1 7.52
CHEMBL43672 — — 1 7.52
CHEMBL43317 — — 1 7.52
CHEMBL296673 — — 1 7.52
CHEMBL47147 — — 1 7.52
CHEMBL42398 — — 1 7.52
CHEMBL441236 — — 1 7.52
CHEMBL417170 — — 1 7.52
CHEMBL42709 — — 1 7.40
CHEMBL296984 — — 1 7.40
CHEMBL297108 — — 1 7.40
CHEMBL42277 — — 1 7.40
CHEMBL298084 — — 1 7.30
CHEMBL42175 — — 1 7.22
CHEMBL46712 — — 1 7.22
CHEMBL295032 — — 1 7.10
CHEMBL43616 — — 1 7.10
CHEMBL42940 — — 1 7.05
CHEMBL290945 — — 1 7.05
CHEMBL44926 — — 1 7.00
CHEMBL432112 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298476 — IC50 = 3.0 nM 8.52
CHEMBL46584 — IC50 = 7.0 nM 8.15
CHEMBL298269 — IC50 = 8.0 nM 8.10
CHEMBL42674 — IC50 = 10.0 nM 8.00
CHEMBL46623 — IC50 = 10.0 nM 8.00
CHEMBL45192 — IC50 = 10.0 nM 8.00
CHEMBL289561 — IC50 = 20.0 nM 7.70
CHEMBL298313 — IC50 = 20.0 nM 7.70
CHEMBL43317 — IC50 = 30.0 nM 7.52
CHEMBL296571 — IC50 = 30.0 nM 7.52
CHEMBL296662 — IC50 = 30.0 nM 7.52
CHEMBL43672 — IC50 = 30.0 nM 7.52
CHEMBL417170 — IC50 = 30.0 nM 7.52
CHEMBL296673 — IC50 = 30.0 nM 7.52
CHEMBL47147 — IC50 = 30.0 nM 7.52
CHEMBL42398 — IC50 = 30.0 nM 7.52
CHEMBL441236 — IC50 = 30.0 nM 7.52
CHEMBL42709 — IC50 = 40.0 nM 7.40
CHEMBL296984 — IC50 = 40.0 nM 7.40
CHEMBL297108 — IC50 = 40.0 nM 7.40
CHEMBL42277 — IC50 = 40.0 nM 7.40
CHEMBL298084 — IC50 = 50.0 nM 7.30
CHEMBL42175 — IC50 = 60.0 nM 7.22
CHEMBL46712 — IC50 = 60.0 nM 7.22
CHEMBL43616 — IC50 = 80.0 nM 7.10
CHEMBL295032 — IC50 = 80.0 nM 7.10
CHEMBL42940 — IC50 = 90.0 nM 7.05
CHEMBL290945 — IC50 = 90.0 nM 7.05
CHEMBL44926 — IC50 = 100.0 nM 7.00
CHEMBL432112 — IC50 = 100.0 nM 7.00
CHEMBL42180 — IC50 = 110.0 nM 6.96
CHEMBL44516 — IC50 = 110.0 nM 6.96
CHEMBL42884 — IC50 = 110.0 nM 6.96
CHEMBL42595 — IC50 = 120.0 nM 6.92
CHEMBL43282 — IC50 = 120.0 nM 6.92
CHEMBL42225 — IC50 = 120.0 nM 6.92
CHEMBL43149 — IC50 = 130.0 nM 6.89
CHEMBL43553 — IC50 = 140.0 nM 6.85
CHEMBL42408 — IC50 = 140.0 nM 6.85
CHEMBL42651 — IC50 = 150.0 nM 6.82
CHEMBL42561 — IC50 = 160.0 nM 6.80
CHEMBL45197 — IC50 = 160.0 nM 6.80
CHEMBL42119 — IC50 = 170.0 nM 6.77
CHEMBL297799 — IC50 = 170.0 nM 6.77
CHEMBL296447 — IC50 = 170.0 nM 6.77
CHEMBL45090 — IC50 = 170.0 nM 6.77
CHEMBL294967 — IC50 = 200.0 nM 6.70
CHEMBL42094 — IC50 = 210.0 nM 6.68
CHEMBL415895 — IC50 = 230.0 nM 6.64
CHEMBL46761 — IC50 = 240.0 nM 6.62