Assay Detail
Binding
CHEMBL762907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | 4.0 | 2 | 8.30 |
| CHEMBL118 | CELECOXIB | 4.0 | 2 | 7.40 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | — | 2 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | IC50 | = | 180.0 | nM | 6.75 |