Assay Detail
Binding
CHEMBL762908
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In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.11 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 8.70 |
| CHEMBL95156 | — | — | 1 | 7.80 |
| CHEMBL420628 | — | — | 1 | 7.64 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.58 |
| CHEMBL94938 | — | — | 1 | 7.47 |
| CHEMBL96098 | — | — | 1 | 7.30 |
| CHEMBL96842 | — | — | 1 | 7.22 |
| CHEMBL94939 | — | — | 1 | 7.17 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 7.09 |
| CHEMBL96947 | — | — | 1 | 7.06 |
| CHEMBL92759 | — | — | 1 | 7.05 |
| CHEMBL92793 | — | — | 1 | 7.00 |
| CHEMBL329120 | — | — | 1 | 6.46 |
| CHEMBL329419 | — | — | 1 | 6.21 |
| CHEMBL92233 | — | — | 1 | 6.08 |
| CHEMBL96950 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL95156 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL420628 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL94938 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL96098 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL96842 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL94939 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL96947 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL92759 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL92793 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL329120 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL329419 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL92233 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL96950 | — | IC50 | = | 1330.0 | nM | 5.88 |