Assay Detail
Binding
CHEMBL762912
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In vitro inhibitory activity against human prostaglandin G/H synthase 2
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.39 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43511 | — | — | 1 | 7.85 |
| CHEMBL40245 | — | — | 1 | 7.70 |
| CHEMBL44152 | — | — | 1 | 7.52 |
| CHEMBL43737 | — | — | 1 | 7.40 |
| CHEMBL44283 | — | — | 1 | 7.30 |
| CHEMBL297008 | — | — | 1 | 7.22 |
| CHEMBL43002 | — | — | 1 | 7.22 |
| CHEMBL44244 | — | — | 1 | 7.22 |
| CHEMBL43736 | — | — | 1 | 7.10 |
| CHEMBL42085 | — | — | 1 | 7.10 |
| CHEMBL42409 | — | — | 1 | 6.92 |
| CHEMBL44038 | — | — | 1 | 6.85 |
| CHEMBL298208 | — | — | 1 | 6.60 |
| CHEMBL294971 | — | — | 1 | 6.33 |
| CHEMBL43957 | — | — | 1 | 6.29 |
| CHEMBL43864 | — | — | 1 | 6.28 |
| CHEMBL43366 | — | — | 1 | 6.12 |
| CHEMBL44313 | — | — | 1 | 5.99 |
| CHEMBL44362 | — | — | 1 | 5.84 |
| CHEMBL44290 | — | — | 1 | 5.79 |
| CHEMBL297820 | — | — | 1 | 5.54 |
| CHEMBL289813 | — | — | 1 | 5.49 |
| CHEMBL44101 | — | — | 1 | 5.41 |
| CHEMBL43664 | — | — | 1 | 5.34 |
| CHEMBL43755 | — | — | 1 | 5.12 |
| CHEMBL43210 | — | — | 1 | 4.99 |
| CHEMBL42801 | — | — | 1 | 4.00 |
| CHEMBL44068 | — | — | 1 | - |
| CHEMBL42121 | — | — | 1 | - |
| CHEMBL44421 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43511 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL40245 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL44152 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL43737 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL44283 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL297008 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL43002 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL44244 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL43736 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL42085 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL42409 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL44038 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL298208 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL294971 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL43957 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL43864 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL43366 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL44313 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL44362 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL44290 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL297820 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL289813 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL44101 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL43664 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL43755 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL43210 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL42801 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL298231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297409 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL43647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44367 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42120 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL296307 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL288773 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298281 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL43863 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44194 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL288570 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44421 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42121 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44068 | — | IC50 | > | 100000.0 | nM | - |