Assay Detail
Binding
CHEMBL762914
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In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cells
88
Total Activities
88
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 143982 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 88 | 7.58 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324312 | — | — | 1 | 8.70 |
| CHEMBL419407 | — | — | 1 | 8.70 |
| CHEMBL332251 | — | — | 1 | 8.52 |
| CHEMBL324509 | — | — | 1 | 8.40 |
| CHEMBL117862 | — | — | 1 | 8.40 |
| CHEMBL115979 | — | — | 1 | 8.30 |
| CHEMBL435381 | CIMICOXIB | 2.0 | 1 | 8.30 |
| CHEMBL326335 | — | — | 1 | 8.22 |
| CHEMBL324826 | — | — | 1 | 8.22 |
| CHEMBL325298 | — | — | 1 | 8.22 |
| CHEMBL117917 | — | — | 1 | 8.15 |
| CHEMBL116016 | — | — | 1 | 8.15 |
| CHEMBL115752 | — | — | 1 | 8.15 |
| CHEMBL327150 | — | — | 1 | 8.15 |
| CHEMBL116683 | — | — | 1 | 8.10 |
| CHEMBL117295 | — | — | 1 | 8.10 |
| CHEMBL118064 | — | — | 1 | 8.05 |
| CHEMBL325894 | — | — | 1 | 8.05 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.05 |
| CHEMBL115410 | — | — | 1 | 7.96 |
| CHEMBL326291 | — | — | 1 | 7.96 |
| CHEMBL333651 | — | — | 1 | 7.96 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.92 |
| CHEMBL118081 | — | — | 1 | 7.89 |
| CHEMBL114783 | — | — | 1 | 7.85 |
| CHEMBL418859 | — | — | 1 | 7.85 |
| CHEMBL117528 | — | — | 1 | 7.82 |
| CHEMBL326097 | — | — | 1 | 7.82 |
| CHEMBL324923 | — | — | 1 | 7.80 |
| CHEMBL331148 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324312 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL419407 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL332251 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL324509 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL117862 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL115979 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL435381 | CIMICOXIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL326335 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL324826 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL325298 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL327150 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL115752 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL116016 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL117917 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL117295 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL116683 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL118064 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL325894 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL115410 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL326291 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL333651 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL118081 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL418859 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL114783 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL117528 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL326097 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL324923 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL331148 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL326270 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL325437 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL117947 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL332725 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL324048 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL117650 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL331278 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL326577 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL117855 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL117306 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL116252 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL324093 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL116343 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL117146 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL117547 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL119852 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL324275 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL324580 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL420869 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL118 | CELECOXIB | IC50 | = | 79.0 | nM | 7.10 |