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Assay Detail

CHEMBL762917

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 2 (CHEMBL230) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB.
J Med Chem (1996) 39 : 1846 -1856
PubMed 8627608 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 7.53 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL52020 — — 1 8.70
CHEMBL52820 — — 1 8.70
CHEMBL55805 — — 1 8.52
CHEMBL54327 — — 1 8.52
CHEMBL300600 — — 1 8.40
CHEMBL54370 — — 1 8.40
CHEMBL296384 — — 1 8.40
CHEMBL51860 — — 1 8.30
CHEMBL54326 — — 1 8.30
CHEMBL443791 — — 1 8.30
CHEMBL57837 — — 1 8.22
CHEMBL52872 — — 1 8.22
CHEMBL52402 — — 1 8.22
CHEMBL293771 — — 1 8.15
CHEMBL299806 — — 1 8.10
CHEMBL52760 — — 1 8.00
CHEMBL416126 — — 1 7.92
CHEMBL417748 — — 1 7.89
CHEMBL55072 — — 1 7.89
CHEMBL55348 — — 1 7.89
CHEMBL418448 — — 1 7.89
CHEMBL442164 — — 1 7.85
CHEMBL54412 — — 1 7.77
CHEMBL54039 — — 1 7.72
CHEMBL52019 — — 1 7.72
CHEMBL300597 — — 1 7.68
CHEMBL54649 — — 1 7.68
CHEMBL300601 — — 1 7.64
CHEMBL55395 — — 1 7.50
CHEMBL442166 — — 1 7.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL52020 — IC50 = 2.0 nM 8.70
CHEMBL52820 — IC50 = 2.0 nM 8.70
CHEMBL54327 — IC50 = 3.0 nM 8.52
CHEMBL55805 — IC50 = 3.0 nM 8.52
CHEMBL300600 — IC50 = 4.0 nM 8.40
CHEMBL54370 — IC50 = 4.0 nM 8.40
CHEMBL296384 — IC50 = 4.0 nM 8.40
CHEMBL51860 — IC50 = 5.0 nM 8.30
CHEMBL54326 — IC50 = 5.0 nM 8.30
CHEMBL443791 — IC50 = 5.0 nM 8.30
CHEMBL57837 — IC50 = 6.0 nM 8.22
CHEMBL52872 — IC50 = 6.0 nM 8.22
CHEMBL52402 — IC50 = 6.0 nM 8.22
CHEMBL293771 — IC50 = 7.0 nM 8.15
CHEMBL299806 — IC50 = 8.0 nM 8.10
CHEMBL52760 — IC50 = 10.0 nM 8.00
CHEMBL416126 — IC50 = 12.0 nM 7.92
CHEMBL417748 — IC50 = 13.0 nM 7.89
CHEMBL55072 — IC50 = 13.0 nM 7.89
CHEMBL55348 — IC50 = 13.0 nM 7.89
CHEMBL418448 — IC50 = 13.0 nM 7.89
CHEMBL442164 — IC50 = 14.0 nM 7.85
CHEMBL54412 — IC50 = 17.0 nM 7.77
CHEMBL54039 — IC50 = 19.0 nM 7.72
CHEMBL52019 — IC50 = 19.0 nM 7.72
CHEMBL300597 — IC50 = 21.0 nM 7.68
CHEMBL54649 — IC50 = 21.0 nM 7.68
CHEMBL300601 — IC50 = 23.0 nM 7.64
CHEMBL55395 — IC50 = 32.0 nM 7.50
CHEMBL442166 — IC50 = 33.0 nM 7.48
CHEMBL292413 — IC50 = 51.0 nM 7.29
CHEMBL294715 — IC50 = 61.0 nM 7.21
CHEMBL52888 — IC50 = 65.0 nM 7.19
CHEMBL298729 — IC50 = 83.0 nM 7.08
CHEMBL55188 — IC50 = 140.0 nM 6.85
CHEMBL299251 — IC50 = 170.0 nM 6.77
CHEMBL54945 — IC50 = 240.0 nM 6.62
CHEMBL291912 — IC50 = 260.0 nM 6.58
CHEMBL54619 — IC50 = 330.0 nM 6.48
CHEMBL52889 — IC50 = 340.0 nM 6.47
CHEMBL54746 — IC50 = 340.0 nM 6.47
CHEMBL52454 — IC50 = 360.0 nM 6.44
CHEMBL6 INDOMETHACIN IC50 = 900.0 nM 6.05
CHEMBL299567 — IC50 = 11400.0 nM 4.94
CHEMBL292607 — IC50 = 52300.0 nM 4.28
CHEMBL55189 — IC50 > 100000.0 nM -
CHEMBL54367 — IC50 > 100000.0 nM -
CHEMBL54605 — IC50 > 100000.0 nM -
CHEMBL294650 — IC50 > 100000.0 nM -
CHEMBL55224 — IC50 > 100000.0 nM -