Assay Detail
Functional
CHEMBL762977
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In vitro antimalarial activity against Plasmodium falciparum HB3 by [3H]hypoxanthine uptake
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.83 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24704 | — | — | 1 | 10.05 |
| CHEMBL284863 | — | — | 1 | 9.74 |
| CHEMBL2368399 | — | — | 1 | 8.96 |
| CHEMBL3037830 | — | — | 1 | 8.89 |
| CHEMBL2368407 | — | — | 1 | 8.85 |
| CHEMBL2368433 | — | — | 1 | 8.80 |
| CHEMBL2368396 | — | — | 1 | 8.68 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.84 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24704 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL284863 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL2368399 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3037830 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2368407 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2368433 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2368396 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 20.0 | nM | 7.70 |